Association of TNF, IL12, and IL23 gene polymorphisms and psoriatic arthritis: meta-analysis

• Published in: Expert review of clinical immunology Vol. 15; no. 3; p. 303
• Main Authors: Loures, Marco Antonio Rocha, Alves, Hugo Vicentin, de Moraes, Amarilis Giaretta, Santos, Thaís da Silva, Lara, Fernanda Formaggi, Neves, Janisleya Silva Ferreira, Macedo, Luciana Conci, Teixeira, Jorge Juarez Vieira, Sell, Ana Maria, Visentainer, Jeane Eliete Laguila
• Format: Journal Article
• Language: English
• Published: England 04.03.2019
• Subjects: Arthritis, Psoriatic - genetics; Arthritis, Psoriatic - immunology; Genetic Predisposition to Disease - genetics; Humans; Interleukin-12 Subunit p40 - genetics; Interleukin-23 Subunit p19 - genetics; Polymorphism, Single Nucleotide; Receptors, Interleukin - genetics; Tumor Necrosis Factor-alpha - genetics; polymorphism genetic; meta-analysis; psoriatic arthritis; Cytokines; Spondylarthropathies
• ISSN: 1744-8409
• DOI: 10.1080/1744666X.2019.1564039

Psoriatic arthritis (PsA) is a chronic skin and joint condition that considerably affects patient quality of life. Several studies have demonstrated different associations of genetic polymorphisms in the pathogenic process of PsA. Therefore, we conducted a meta-analysis to estimate the effect of polymorphisms in the cytokines TNF, IL12B, IL23A, and IL23R on PsA risk. We screened 1,097 abstracts and identified 14 relevant studies published between January 2007 and December 2017. A systematic search was conducted in PubMed, Web of Knowledge and Scopus databases. Meta-analyses were performed for the comparisons of alleles and multiple genetic models. Among the cytokines studied, we found 17 polymorphisms that were the most investigated. The association to PsA was observed in the presence of polymorphisms: TNF-238 G > A (rs361525), -308 G > A (rs1800629), and -857 C > T (rs1799724); IL12B C > G (rs6887695) and A > C (rs3212227); IL23A A > G (rs2066808) and IL23R G > A (rs11209026). Our findings suggest that these variant cytokine genes may strongly influence the immunological response of PsA.