Long-term side effects of glucocorticoids

Glucocorticoids represent the standard therapy for reducing inflammation and immune activation in various diseases. However, as with any potent medication, they are not without side effects. Glucocorticoid-associated side effects may involve most major organ systems. Musculoskeletal, gastrointestina...

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Bibliographic Details
Published inExpert opinion on drug safety Vol. 15; no. 4; p. 457
Main Authors Oray, Merih, Abu Samra, Khawla, Ebrahimiadib, Nazanin, Meese, Halea, Foster, C Stephen
Format Journal Article
LanguageEnglish
Published England 02.04.2016
Subjects
Drug Monitoring
Drug-Related Side Effects and Adverse Reactions - prevention & control
Glucocorticoids - adverse effects
Glucocorticoids - therapeutic use
Humans
Risk
immunosuppression
side effects
glucocorticoids
corticosteroids
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Summary:Glucocorticoids represent the standard therapy for reducing inflammation and immune activation in various diseases. However, as with any potent medication, they are not without side effects. Glucocorticoid-associated side effects may involve most major organ systems. Musculoskeletal, gastrointestinal, cardiovascular, endocrine, neuropsychiatric, dermatologic, ocular, and immunologic side effects are all possible. This article analyzes English-language literature and provides an update on the most recent literature regarding side effects of systemic glucocorticoid treatment. The risk/benefit ratio of glucocorticoid therapy can be improved by proper use. Careful monitoring and using appropriate preventive strategies can potentially minimize side effects.
ISSN:1744-764X
DOI:10.1517/14740338.2016.1140743