Liposome: composition, characterisation, preparation, and recent innovation in clinical applications

• Published in: Journal of drug targeting Vol. 27; no. 7; pp. 742 - 761
• Main Authors: Ahmed, Kamel S., Hussein, Saied A., Ali, Abdelmoneim H., Korma, Sameh A., Lipeng, Qiu, Jinghua, Chen
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 09.08.2019
• Subjects: applications; cancer; drug delivery; Liposomes; phospholipids; wound healing; wound healing; cancer; Liposomes; drug delivery; phospholipids; applications
• ISSN: 1061-186X; 1029-2330; 1029-2330
• DOI: 10.1080/1061186X.2018.1527337

In the last decades, pharmaceutical interested researches aimed to develop novel and innovative drug delivery techniques in the medical and pharmaceutical fields. Recently, phospholipid vesicles (Liposomes) are the most known versatile assemblies in the drug delivery systems. The discovery of liposomes arises from self-forming enclosed phospholipid bilayer upon coming in contact with the aqueous solution. Liposomes are uni or multilamellar vesicles consisting of phospholipids produced naturally or synthetically, which are readily non-toxic, biodegradable, and are readily produced on a large scale. Various phospholipids, for instance, soybean, egg yolk, synthetic, and hydrogenated phosphatidylcholine consider the most popular types used in different kinds of formulations. This review summarises liposomes composition, characterisation, methods of preparation, and their applications in different medical fields including cancer therapy, vaccine, ocular delivery, wound healing, and some dermatological applications.