Care of patients coinfected with HIV and hepatitis C virus: 2007 updated recommendations from the HCV–HIV International Panel

• Published in: AIDS (London) Vol. 21; no. 9; pp. 1073 - 1089
• Main Authors: Soriano, Vincent, Puoti, Massimo, Sulkowski, Mark, Cargnel, Antonietta, Benhamou, Yves, Peters, Marion, Mauss, Stefan, Bräu, Norbert, Hatzakis, Angelos, Pol, Stanislas, Rockstroh, Juergen
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott Williams & Wilkins 31.05.2007
• Subjects: Anti-HIV Agents - therapeutic use; Anti-Retroviral Agents - adverse effects; Antiviral Agents - administration & dosage; Biological and medical sciences; Chemical and Drug Induced Liver Injury; Drug Administration Schedule; Drug Interactions; Hepatitis C virus; Hepatitis C, Chronic - complications; Hepatitis C, Chronic - drug therapy; Hepatitis C, Chronic - enzymology; HIV Infections - complications; HIV Infections - drug therapy; HIV Infections - enzymology; Human immunodeficiency virus; Human viral diseases; Humans; Immunodeficiencies; Immunodeficiencies. Immunoglobulinopathies; Immunopathology; Infectious diseases; Interferons - administration & dosage; Liver Cirrhosis - etiology; Liver Cirrhosis - pathology; Medical sciences; Ribavirin - administration & dosage; Transaminases - analysis; Viral diseases; Viral diseases of the lymphoid tissue and the blood. Aids; Viral hepatitis; Immunopathology; Mixed infection; liver; Cytokine; Hepatic disease; AIDS; Immune deficiency; Recommendation; Ribavirin; Infection; Virus; HIV; Viral disease; Nucleoside analog; Digestive diseases; Antiviral; Interferon; HCV; Flaviviridae; Hepatitis C virus; Hepacivirus; Viral hepatitis C
• ISSN: 0269-9370
• DOI: 10.1097/QAD.0b013e3281084e4d

Chronic hepatitis C (HCV) infection is currently one of the most clinically relevant comorbidities in the HIV population; overall, it affects one third of HIV-positive individuals. Progression to end-stage liver disease occurs faster in coinfected patients and decompensated cirrhosis is one of the main causes of hospitalization and death in this population. However, the risk of hepatotoxicity using antiretroviral drugs is increased in subjects with underlying HCV infection. Therefore, the optimal management of chronic HCV in HIV-positive patients is currently a priority.