Parental factors impacting the enrollment of children in cardiac critical care clinical trials

• Published in: Pediatric cardiology Vol. 28; no. 3; pp. 167 - 171
• Main Authors: Hoffman, T M, Taeed, R, Niles, J P, McMillin, M A, Perkins, L A, Feltes, T F
• Format: Journal Article
• Language: English
• Published: United States Springer 01.06.2007
• Subjects: Adolescent; Adult; Child; Child, Preschool; Clinical trials; Clinical Trials as Topic - legislation & jurisprudence; Clinical Trials as Topic - psychology; Critical Care; Female; Heart Diseases - therapy; Humans; Infant; Infant, Newborn; Male; Parents; Parents - psychology; Pediatric cardiology; Surveys; Surveys and Questionnaires; United States
• ISSN: 0172-0643; 1432-1971
• DOI: 10.1007/s00246-006-0020-5

Clinical trials are abundant in adult cardiovascular medicine; however, they are rare in pediatric cardiology. Pediatric cardiac trial design may be impacted by the heterogeneous nature of the underlying cardiac defects, as well as by a strong emotional response from parents whose child will undergo a surgical intervention. The purpose of this study was to assess factors that may have an impact on parents considering enrollment of their child in a clinical trial at the time of surgical intervention. A voluntary, self-administered questionnaire (14 questions) was provided to parents of children 16 years of age or younger during the preadmission testing period. Demographic and procedure-related variables were collected for each patient. A total of 119 surveys were analyzed over a 1.5-year period. Only 8% of the parents had their child participate in a clinical trial in the past. Fifty-six percent of the parents preferred that their child's cardiologist or surgeon explain clinical trial details, with 23% preferring the principal investigator and 3% preferring the research coordinator. Fifty percent of the parents were favorably disposed to participate in a clinical trial if the drug or device was currently used by their child's doctor, and 19% were encouraged to participate if the drug or device was approved for use in adults. The majority of parents (64%) preferred to be asked about participating in a trial within 1 month prior to the planned procedure, and 40% preferred to discuss trial details at a remote time in an outpatient location. Sixty-three percent of parents believed that most of the medications currently used in children were already approved by the Food and Drug Administration. Most parents (91%) believed that clinical trials conducted in children will help improve pediatric health care; 74% believed that their child may receive potential benefit from enrolling in a trial. Finally, 43% believed that funding for trials should come from government and health care agencies, as opposed to pharmaceutical companies (24%). This survey reveals the importance of the attending physician and timing in educating parents regarding a cardiac critical care clinical trial. These data may impact the design and successful conduct of future trials.