Methylphenidate, neuroleptics and dyskinesia-dystonia

Methlyphenidate is one of two stimulant drugs used in the management of the Hyperkinetic Reaction in children. It has been known to have side effects such as dyskinesia, but this case details the emergence of dystonia and dyskinesia when the simultaneous use of methylphenidate and a phenothiazine wa...

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Bibliographic Details
Published inCanadian journal of psychiatry Vol. 25; no. 3; p. 254
Main Authors Husain, A, Chapel, J, Malek-Ahmadi, P
Format Journal Article
LanguageEnglish
Published United States 01.04.1980
Subjects
Asthma - drug therapy
Child, Preschool
Drug Therapy, Combination
Dyskinesia, Drug-Induced - etiology
Dystonia - chemically induced
Humans
Hyperkinesis - drug therapy
Male
Methylphenidate - adverse effects
Methylphenidate - therapeutic use
Theophylline - therapeutic use
Thioridazine - adverse effects
Thioridazine - therapeutic use
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Summary:Methlyphenidate is one of two stimulant drugs used in the management of the Hyperkinetic Reaction in children. It has been known to have side effects such as dyskinesia, but this case details the emergence of dystonia and dyskinesia when the simultaneous use of methylphenidate and a phenothiazine was followed by withdrawal of the phenothiazine. It is postulated that the use of phenothiazine resulted in a post-synaptic supersensitivity which precipitated dystonia and dyskinesia when phenothiazine was withdrawn and methylphenidate reinstituted. It is also suggested that the phenothiazine dopamine-blocking action may necessitate the use of larger quantities of stimulant in order to produce the desired effect.
ISSN:0706-7437
DOI:10.1177/070674378002500309