Effect of Bushen Huoxue recipe on women with thin endometrial ovulation disorder and a rat model of thin endometrium resulted from kidney deficiency-related blood stasis

• Published in: Gynecological endocrinology Vol. 37; no. 5; pp. 433 - 437
• Main Authors: Yin, Xiao-Dan, Xue, Xiao-Ou, Wang, Jing-Shang, Yang, Wei, He, Jun-Qin
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 04.05.2021
• Subjects: Adult; Animals; Bushen Huoxue recipe (BHR); Disease Models, Animal; Drug Evaluation, Preclinical; Drugs, Chinese Herbal - pharmacology; Drugs, Chinese Herbal - therapeutic use; Endometrium; Endometrium - drug effects; Female; Humans; kidney deficiency-related blood stasis; Kidney Diseases - complications; Ovulation; Pilot Projects; Pregnancy; Pregnancy Rate; Rats; Rats, Sprague-Dawley; Uterine Artery - drug effects; Uterine Diseases - drug therapy; Uterine Diseases - etiology; kidney deficiency-related blood stasis; Bushen Huoxue recipe (BHR); Endometrium
• ISSN: 0951-3590; 1473-0766
• DOI: 10.1080/09513590.2020.1781079

To examine the therapeutic effect of Bushen Huoxue recipe (BHR) on women with thin endometrial ovulation disorder and on a rat model of kidney deficiency-related blood stasis. A total of 60 women with thin endometrial ovulation disorder was enrolled. The primary outcome of the study was the pregnancy rate three menstrual cycles after treatment. The study also examined the changes in the type and thickness of uterine artery, uterine artery pulsatility index (PI) and endometrial resistance index (RI). To establish kidney deficiency-related blood stasis in Sprague Dawley (SD) rats, an intragastric administration of hydroxyurea and a tail vein injection of Dextran were given, following with a flashing of the uterine cavity with 95% anhydrous ethanol. A combined regimen of BHR and estradiol valerate significantly increased the rate of pregnancy in women with thin endometrial ovulation disorder. The treatment was accompanied by a significant increase in endometrial thickness and decreases in uterine artery PI and endometrial RI. In rats, kidney deficiency-related blood stasis caused severe loss in endometrial architecture, thickness, and numbers of gland and blood vessel compared to the healthy SD rats. Treatment with BHR could ameliorate the endometrial damages associated with kidney deficiency-related blood stasis.