Role of cervical cerclage and prolonged antibiotic therapy with azithromycin in patients with previous perinatal loss amnionitis

• Published in: The journal of maternal-fetal & neonatal medicine Vol. 30; no. 3; p. 309
• Main Authors: Illia, R, Leveque, R, Mayer, H, de Anchorena, M, Uranga Imaz, M, Habich, D
• Format: Journal Article
• Language: English
• Published: England 01.02.2017
• Subjects: Adult; Anti-Bacterial Agents - therapeutic use; Azithromycin - therapeutic use; Cerclage, Cervical; Chorioamnionitis - etiology; Chorioamnionitis - prevention & control; Drug Administration Schedule; Female; Fetal Death - etiology; Fetal Death - prevention & control; Humans; Pregnancy; Premature Birth - etiology; Premature Birth - prevention & control; Prospective Studies; Risk Factors; Treatment Outcome; Amnionitis; antibiotics; preterm delivery; cervical cerclaje
• ISSN: 1476-4954
• DOI: 10.3109/14767058.2016.1171312

In the group of 35 patients with cerclage, intermediate fetal mortality was reduced from 37.1% to 0 (p < 0.001); late fetal mortality rate from 8.5% to 2.8% (p = 0.606); prematurity from 65.7% to 5.7% (p < 0.001); newborn underweight from 11.4% to 5.7% (p = 0.671); newborns with very low weight from 34.2% to 0 (p < 0.001) and the abortion rate from 8.5% to 0 ( p  < 0.001). In the group of 19 patients without buckling, intermediate fetal mortality was reduced from 26.3% to 10.5% (p = 402); late fetal mortality from 63.1% to 0 (p < 0.001); prematurity 78.9% to 31.5% (p < 0.009); the newborn of low weight from 31.5% to 10.5% (p = 0.234); newborns with very low weight from 68.4% to 15.7% (p < 0.003) and the abortion rate from 36.8 to 0 (p < 0.001). In conclusion, we believe the results of this study demonstrate the effectiveness of therapeutic and prophylactic cervical cerclage associated with prolonged antibiotic therapy.