Spaceflight induced changes in the human proteome

Spaceflight is one of the most extreme conditions encountered by humans: Individuals are exposed to radiation, microgravity, hypodynamia, and will experience isolation. A better understanding of the molecular processes induced by these factors may allow us to develop personalized countermeasures to...

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Bibliographic Details
Published inExpert review of proteomics Vol. 14; no. 1; p. 15
Main Authors Kononikhin, Alexey S, Starodubtseva, Natalia L, Pastushkova, Lyudmila Kh, Kashirina, Daria N, Fedorchenko, Kristina Yu, Brhozovsky, Alexander G, Popov, Igor A, Larina, Irina M, Nikolaev, Evgeny N
Format Journal Article
LanguageEnglish
Published England 02.01.2017
Subjects
Humans
Proteome - genetics
Proteomics
Space Flight
Weightlessness - adverse effects
microgravity
proteomics
human proteome
Spaceflight
MARS 500
spaceflight simulation
dry immersion
bed rest study
extreme conditions
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Summary:Spaceflight is one of the most extreme conditions encountered by humans: Individuals are exposed to radiation, microgravity, hypodynamia, and will experience isolation. A better understanding of the molecular processes induced by these factors may allow us to develop personalized countermeasures to minimize risks to astronauts. Areas covered: This review is a summary of literature searches from PubMed, NASA, Roskosmos and the authors' research experiences and opinions. The review covers the available proteomic data on the effects of spaceflight factors on the human body, including both real space missions and ground-based model experiments. Expert commentary: Overall, the authors believe that the present background, methodology and equipment improvements will enhance spaceflight safety and support accumulation of new knowledge on how organisms adapt to extreme conditions.
ISSN:1744-8387
DOI:10.1080/14789450.2017.1258307