Autograft cellular composition and outcome in NHL patients: results of the prospective multicenter GOA study

Autologous stem cell transplantation (auto-SCT) is an established treatment option in patients with non-Hodgkin lymphoma (NHL). In this prospective multicenter study, the effect of infused blood graft cellular composition on post-transplant outcome was analyzed in 129 NHL patients. Higher graft CD34...

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Published inLeukemia & lymphoma Vol. 61; no. 9; pp. 2082 - 2092
Main Authors Turunen, Antti, Valtola, Jaakko, Partanen, Anu, Ropponen, Antti, Kuittinen, Outi, Kuitunen, Hanne, Vasala, Kaija, Ågren, Lasse, Penttilä, Karri, Keskinen, Leena, Savolainen, Eeva-Riitta, Pyörälä, Marja, Kuittinen, Taru, Selander, Tuomas, Mäntymaa, Pentti, Pelkonen, Jukka, Jantunen, Esa, Varmavuo, Ville
Format Journal Article
LanguageEnglish
Published United States Taylor & Francis 28.07.2020
Subjects
Autografts
autologous stem cell transplantation
Disease-Free Survival
flow cytometry
graft cellular composition
Hematopoietic Stem Cell Transplantation
Humans
Lymphoma, Non-Hodgkin - therapy
Non-Hodgkin lymphoma
outcome
Prospective Studies
Transplantation, Autologous
Treatment Outcome
Non-Hodgkin lymphoma
graft cellular composition
flow cytometry
outcome
autologous stem cell transplantation
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Summary:Autologous stem cell transplantation (auto-SCT) is an established treatment option in patients with non-Hodgkin lymphoma (NHL). In this prospective multicenter study, the effect of infused blood graft cellular composition on post-transplant outcome was analyzed in 129 NHL patients. Higher graft CD34 + cell content (>2.5 × 10 6 /kg) correlated with better progression-free survival (PFS) (p=.009) and overall survival (OS) (p=.004). Higher graft CD34 + CD133 + CD38 - counts (>0.08 × 10 6 /kg) were also linked with better PFS (p=.03) and OS (p=.004), and these survival benefits retained in multivariate analyses. Higher infused CD3 + CD4 + cell count (>37 × 10 6 /kg) predicted better PFS (p=.013) and OS (p=.007) in multivariate analysis. Autograft cellular composition seems to impact outcome in NHL patients. These observations regarding composition of optimal graft in autologous setting should be validated in an independent patient series or in a randomized study.
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ISSN:1042-8194
1029-2403
DOI:10.1080/10428194.2020.1762879