Atriplex halimus aqueous extract abrogates carbon tetrachloride-induced hepatotoxicity by modulating biochemical and histological changes in rats

• Published in: Archives of physiology and biochemistry Vol. 126; no. 1; pp. 49 - 60
• Main Authors: Slama, Kheira, Boumendjel, Mahieddine, Taibi, Faiza, Boumendjel, Amel, Messarah, Mahfoud
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 01.01.2020
• Subjects: Animals; Antioxidants - chemistry; Antioxidants - pharmacology; Atriplex - chemistry; Atriplex halimus; Biphenyl Compounds - antagonists & inhibitors; carbon tetrachloride; Carbon Tetrachloride - toxicity; Catalase - metabolism; Chemical and Drug Induced Liver Injury - metabolism; Chemical and Drug Induced Liver Injury - pathology; Chemical and Drug Induced Liver Injury - prevention & control; Drug Administration Schedule; Gene Expression - drug effects; Glutathione - metabolism; Glutathione Peroxidase - metabolism; Glutathione Transferase - metabolism; hepatotoxicity; Lipid Peroxidation - drug effects; Liver - drug effects; Liver - metabolism; Liver - pathology; Male; Malondialdehyde - metabolism; oxidative stress; Oxidative Stress - drug effects; Picrates - antagonists & inhibitors; Plant Extracts - chemistry; Plant Extracts - pharmacology; Plant Leaves - chemistry; Rats; Rats, Wistar; Superoxide Dismutase - metabolism; Atriplex halimus; carbon tetrachloride; rats; hepatotoxicity; oxidative stress
• ISSN: 1381-3455; 1744-4160
• DOI: 10.1080/13813455.2018.1489852

The objective of this study was to evaluate the potential protective effect of Atriplex halimus aqueous leaves extract (AHAE) against acute carbon tetrachloride (CCl 4 )-induced oxidative stress in rats. Rats were randomly divided into four groups: group (C) served as a control treated with 1 ml/(kg bw) of olive oil, and group (CCl 4 ) was treated with 1 ml CCl 4 /(kg bw) dissolved in olive oil administered by intraperitoneal way. Rats of group (CCl 4 +AHAE) have received CCl 4 and treated with 200 mg AHAE/(kg bw). Animals of group (AHAE) were treated with 200 mg/(kg bw) of AHAE. A significant increase in malondialdehyde levels in liver associated with a decrease in antioxidant enzyme activities and reduced glutathione content was observed in CCl 4 group compared to controls. The administration of AHAE to CCl 4 +AHAE group improved all parameters studied. We conclude that CCl 4 induces oxidative stress and modifies biochemical parameters and histological aspects of liver. Administration of AHAE alleviates the toxicity induced by this organic compound.