Genetic polymorphisms of molecules associated with inflammation and immune response in Japanese subjects with functional dyspepsia
Inflammatory changes in the gastric mucosa are commonly observed in Japanese patients with functional dyspepsia (FD). However, detailed data regarding the relationship between the genetic regulatory factors of inflammation and FD are not available. We investigated the associations between FD and gen...
Saved in:
Published in | International journal of molecular medicine Vol. 20; no. 5; pp. 717 - 723 |
---|---|
Main Authors | , , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Greece
D.A. Spandidos
01.11.2007
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Summary: | Inflammatory changes in the gastric mucosa are commonly observed in Japanese
patients with functional dyspepsia (FD). However, detailed data regarding the
relationship between the genetic regulatory factors of inflammation and FD are
not available. We investigated the associations between FD and genetic polymorphisms
of molecules associated with inflammation or immune response (IL-17A, -17F and
MIF). The study was performed with 278 subjects (188 with no upper abdominal symptoms
and 90 with FD according to the Roma III criteria). We employed the PCR-SSCP (multiplex
PCR for IL-17A and -17F) method to detect the gene polymorphisms. Overall, the
polymorphisms of the IL-17A, -17F and MIF genes were not correlated with the susceptibility
to FD. However, the MIF -173C allele carrier had a significantly increased risk
for the development of epigastric pain syndrome (EPS) of FD (OR, 2.12; 95% CI,
1.00-4.49; p=0.0497). In Helicobacter pylori (H. pylori)-infected cases, the number
of IL-17F 7488T alleles was positively correlated with the development of EPS
(OR, 11.3; 95% CI, 1.23-103.2; p=0.032), while the IL-17F T/T homozygote and the
MIF -173C carrier had an increased risk for EPS (OR, 10.4; 95% CI, 1.17-92.3;
p=0.036 and OR, 3.66; 95% CI, 1.19-11.3; p=0.024, respectively). In addition,
a significant interaction between the IL-17F 7488 polymorphism and H. pylori infection
was shown to increase the activity and inflammation scores (p=0.043 and 0.042,
respectively). There were no significant associations between the IL-17A polymorphism
and FD. Our results provide the first evidence that the IL-17F and MIF gene polymorphisms
are significantly associated with the development of FD, particularly EPS, a subgroup
of FD, in H. pylori-infected subjects. The genetic polymorphisms of inflammation
or immune response-related molecules are involved in the development of one of
the FD subgroups via H. pylori-induced gastric inflammation. |
---|---|
Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 1107-3756 1791-244X |
DOI: | 10.3892/ijmm.20.5.717 |