Association of +1923C > T, -1112C > T and +2044A > G Polymorphisms in IL-13 Gene with Susceptibility to Pediatric Asthma: A Systematic Review and Meta-Analysis

• Published in: Fetal and pediatric pathology Vol. 41; no. 2; pp. 259 - 277
• Main Authors: Aarafi, Hossein, Yadegari, Amirhossein, Dastgheib, Seyed Alireza, Bahrami, Reza, Shajari, Ahmad, Nafei, Zahra, Moghimi, Mansour, Mirjalili, Seyed Reza, Neamatzadeh, Hossein
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 04.03.2022
• Subjects: Asians; Asthma; Asthma - genetics; Child; Genetic Predisposition to Disease; Humans; interleukin 13; Interleukin-13 - genetics; meta-analysis; pediatric; polymorphism; Polymorphism, Single Nucleotide; meta-analysis; polymorphism; interleukin 13; Asthma; pediatric
• ISSN: 1551-3815; 1551-3823
• DOI: 10.1080/15513815.2020.1783406

Background Previous studies have provided conflicting evidence implicating the IL-13 polymorphism and pediatric asthma. Thus, we performed a meta-analysis to combine and analyze the available studies to provide more accurate conclusions. Methods: A comprehensive retrieval in PubMed, EMBASE, Web of Science, and CNKI was performed up to February 05, 2020. Results: A total of 39 case-control studies including 15 studies with 4,968 cases and 7,091 controls were on +1923 C > T, ten studies with 3,175 cases and 2,983 controls on -1112 C > T, and 14 studies with 4,476 cases and 5,121 controls on +2044 A > G were selected. Pooled data showed that the IL-13 + 1923 C > T, −1112 C > T and +2044 A > G polymorphisms were significantly associated with risk of pediatric asthma. The IL-13 + 1923 C > T (Asians and Africans), −1112 C > T (Caucasians) and +2044 A > G (Asians) polymorphisms were more frequently associated in these ethnic groups. Conclusions: Our pooled data indicated that IL-13 + 1923 C > T, −1112 C > T and +2044 A > G polymorphisms were correlated with risk of pediatric asthma.