Plasma myostatin levels are related to the extent of right ventricular dysfunction in exacerbation of chronic obstructive pulmonary disease

• Published in: Biomarkers Vol. 22; no. 3-4; pp. 246 - 252
• Main Authors: Ju, Chun-Rong, Zhang, Jian-Heng, Chen, Miao, Chen, Rong-Chang
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 19.05.2017
• Subjects: Aged; Biomarkers - blood; Case-Control Studies; Chronic obstructive pulmonary disease; Female; Humans; Male; Multivariate Analysis; myostatin; Myostatin - blood; pulmonary arterial hypertension; Pulmonary Disease, Chronic Obstructive - blood; Pulmonary Disease, Chronic Obstructive - complications; Pulmonary Disease, Chronic Obstructive - diagnosis; right ventricle; tricuspid annular plane systolic excursion; Tricuspid Valve - physiopathology; Ventricular Dysfunction, Right - blood; Ventricular Dysfunction, Right - diagnosis; Ventricular Dysfunction, Right - etiology; tricuspid annular plane systolic excursion; Chronic obstructive pulmonary disease; right ventricle; pulmonary arterial hypertension; myostatin
• ISSN: 1354-750X; 1366-5804
• DOI: 10.1080/1354750X.2016.1203999

Objective: To investigate the relationship between plasma myostatin levels and right ventricle (RV) dysfunction (RVD) in acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Methods: The study recruited 84 patients with AECOPD. Plasma myostatin was analyzed and tricuspid annular plane systolic excursion (TAPSE) < 16 mm was used as the main indicator for RVD. Results: Plasma myostatin levels were significantly higher in 47 patients with RVD than 37 ones without (P < 0.005). Multivariate regression analysis revealed that myostatin levels correlated significantly with TAPSE values and RV myocardial performance index (p < 0.001) among the study patients. Conclusion: Plasma myostatin is a potential biomarker for improving diagnosis of RVD in AECOPD.