Reduction of the Lamina Cribrosa Curvature After Trabeculectomy in Glaucoma

• Published in: Investigative ophthalmology & visual science Vol. 57; no. 11; pp. 5006 - 5014
• Main Authors: Lee, Seung Hyen, Yu, Da-Ae, Kim, Tae-Woo, Lee, Eun Ji, Girard, Michaël J A, Mari, Jean Martial
• Format: Journal Article
• Language: English
• Published: United States Association for Research in Vision and Ophthalmology 01.09.2016
• Subjects: Human health and pathology; Life Sciences; Sensory Organs; OPTIC-NERVE HEAD; COHERENCE TOMOGRAPHY IMAGES; REGIONAL DIFFERENCES; lamina cribrosa; trabeculectomy; INTRAOCULAR-PRESSURE; optic nerve head; curvature; OCULAR HYPERTENSION TREATMENT; OPEN-ANGLE GLAUCOMA; BIOMECHANICAL STRUCTURE; DISPLACEMENT; CHOROIDAL THICKNESS; reduction; DEPTH
• ISSN: 1552-5783; 0146-0404; 1552-5783
• DOI: 10.1167/iovs.15-18982

To investigate whether the lamina cribrosa (LC) curvature is decreased after trabeculectomy. Thirty-nine eyes of 39 patients with primary open-angle glaucoma who underwent trabeculectomy were included. Optic nerves were scanned by using enhanced-depth-imaging spectral-domain optical coherence tomography before and after trabeculectomy. The LC curvature was assessed by measuring the LC curvature index (LCCI) in seven horizontal B-scan images in each eye. The LCCI was significantly smaller at postoperative 6 months than at the preoperative level in all seven planes (all P < 0.001). Preoperative LCCI was associated with younger age at superior midperiphery, midhorizontal plane, inferior midperiphery (all P ≤ 0.005) and higher preoperative intraocular pressure (IOP) at superior and inferior midperiphery (both P = 0.039). Younger age and larger preoperative LCCI were associated with a larger reduction of the LCCI at all three locations (P = 0.003 and 0.031 at superior midperiphery, P = 0.011 and 0.001 at midhorizontal plane, and P = 0.014 and 0.005 at inferior midperiphery, respectively), whereas the percentage IOP lowering was associated at superior and inferior midperiphery (P = 0.017 and 0.047, respectively). Lamina cribrosa curvature was reduced after trabeculectomy. This finding suggests that LC curvature may have value as a parameter relevant to optic nerve head biomechanics.