Exacerbated prognostic impact of multiple intramural metastasis versus single intramural metastasis of thoracic esophageal squamous cell carcinoma: evidence from an Uzbekistan cohort

• Published in: Surgery today (Tokyo, Japan) Vol. 54; no. 7; pp. 771 - 778
• Main Authors: Yusupbekov, Abrorjon, Shinozuka, Takahiro, Juraev, Elyor, Usmanov, Bekzod, Kanda, Mitsuro, Sakamoto, Junichi, Tuychiev, Otabek
• Format: Journal Article
• Language: English
• Published: Singapore Springer Nature Singapore 01.07.2024
• Subjects: Age Factors; Aged; Carcinoma, Squamous Cell - mortality; Carcinoma, Squamous Cell - pathology; Carcinoma, Squamous Cell - secondary; Carcinoma, Squamous Cell - surgery; Cohort Studies; Esophageal Neoplasms - mortality; Esophageal Neoplasms - pathology; Esophageal Neoplasms - surgery; Esophageal Squamous Cell Carcinoma - mortality; Esophageal Squamous Cell Carcinoma - pathology; Esophageal Squamous Cell Carcinoma - secondary; Esophageal Squamous Cell Carcinoma - surgery; Esophagectomy; Female; Humans; Lymphatic Metastasis; Male; Medicine; Medicine & Public Health; Middle Aged; Neoplasm Metastasis; Neoplasm Staging; Original Article; Prognosis; Retrospective Studies; Surgery; Surgical Oncology; Survival Rate; Uzbekistan - epidemiology; Uzbekistan; Esophageal cancer; Intramural metastasis; Republic of Uzbekistan
• ISSN: 0941-1291; 1436-2813; 1436-2813
• DOI: 10.1007/s00595-023-02790-x

Purpose Intramural metastasis (IM) is a poor prognostic factor for patients with esophageal squamous cell carcinoma (ESCC). We conducted this study to assess the prognostic impact of IM in an Uzbekistan cohort and to identify the factors associated with the poor prognosis of patients with ESCC and IM. Methods The subjects of this retrospective analysis were 1083 patients with thoracic ESCC, who underwent curative esophagectomy between 2001 and 2021 at the National Cancer Center of Uzbekistan. We compared the clinicopathological characteristics and survival outcomes of patients with versus those without IM and evaluated the factors associated with the poor prognosis of patients with IM. Results Patients with pathological IM ( n  = 59, 5.4%) were significantly older, had a higher percentage of lymphatic invasion and worse pathological N stage, and had shorter overall survival (OS) than patients without IM. Multivariable analysis of OS identified multiple IMs as the only independent prognostic factor in patients with IM (hazard ratio, 6.04; 95% confidence interval, 2.77–13.18; P  < 0.001). Patients with multiple IMs had shorter OS and recurrence-free survival than those with a single IM. Conclusion IM was a poor prognostic factor for patients with ESCC in this Uzbekistan cohort and multiple IMs were associated with worse outcomes.