The roles and mechanisms of G3BP1 in tumour promotion

Ras-GTPase-activating protein SH3 domain-binding protein 1 (G3BP1) is a SH3 domain-binding protein that is overexpressed in a variety of tumour tissues and cancers, such as head and neck cancer, lung cancer, prostate cancer, colon cancer and breast cancer. G3BP1 promotes tumour cell proliferation an...

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Published inJournal of drug targeting Vol. 27; no. 3; pp. 300 - 305
Main Authors Zhang, Cong-Hui, Wang, Jun-Xia, Cai, Mei-Lian, Shao, Rongguang, Liu, Hong, Zhao, Wu-Li
Format Journal Article
LanguageEnglish
Published England Taylor & Francis 16.03.2019
Subjects
anti-cancer therapy
apoptosis
metastasis
polyphenolic compounds
Ras-GTPase-activating protein SH3 domain-binding protein 1
tumour
anti-cancer therapy
apoptosis
Ras-GTPase-activating protein SH3 domain-binding protein 1
metastasis
tumour
polyphenolic compounds
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Summary:Ras-GTPase-activating protein SH3 domain-binding protein 1 (G3BP1) is a SH3 domain-binding protein that is overexpressed in a variety of tumour tissues and cancers, such as head and neck cancer, lung cancer, prostate cancer, colon cancer and breast cancer. G3BP1 promotes tumour cell proliferation and metastasis and inhibits apoptosis by regulating the Ras, TGF-β/Smad, Src/FAK and p53 signalling pathways. At present, polypeptides targeting G3BP1 have shown anti-tumour activity and G3BP1 also involved in anti-cancer effects of some polyphenolic compounds (resveratrol and EGCG). Therefore G3BP1 may be a potential target for tumour treatment.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:1061-186X
1029-2330
DOI:10.1080/1061186X.2018.1523415