The safety of available chemo-free treatments for mantle cell lymphoma

• Published in: Expert opinion on drug safety Vol. 19; no. 11; p. 1377
• Main Authors: Korycka-Wołowiec, Anna, Wołowiec, Dariusz, Robak, Tadeusz
• Format: Journal Article
• Language: English
• Published: England 01.11.2020
• Subjects: Aged; Antineoplastic Agents - administration & dosage; Antineoplastic Agents - adverse effects; Humans; Lymphoma, Mantle-Cell - pathology; Lymphoma, Mantle-Cell - therapy; Molecular Targeted Therapy; Precision Medicine; Prognosis; Recurrence; Survival Rate; ibrutinib; zanubrutinib; safety profile; veneotoclax; mantle cell lymphoma; clinical efficacy; Acalabrutinib; bortezomib
• ISSN: 1744-764X
• DOI: 10.1080/14740338.2020.1826435

Conventional treatment for mantle cell lymphoma (MCL) patients includes regimens combining rituximab with other cytotoxic drugs, followed or not by consolidation with autologous stem cell transplantation and rituximab maintenance. However, older, unfit, and relapsed/refractory patients are often ineligible for intense treatment. Currently, available new targeted treatment options seem to offer hope in this group of patients. This article reviews the safety profiles of new therapeutic chemotherapy-free options for MCL patients. Publications in English from 2010 through June 2020 were surveyed on the MEDLINE database for articles. Proceedings of the American Society of Hematology during the last 5 years were also included. MCL is a clinically heterogenous disease predominantly affecting elderly patients. Its variable clinical course requires personalization and individualization of treatment to achieve optimal survival and acceptable safety profiles, especially in poor prognosis patients. Results of clinical trials performed in the past decade indicated that novel drugs used as a single agent or as part of a conventional chemotherapeutic treatment offer promise in minimalizing the relapse rate for MCL and may allow more effective and safer treatment options by reducing the risk of adverse events, especially cytopenias and infections.