LRRK2 and human disease: a complicated question or a question of complexes?
Leucine-rich repeat kinase 2 (LRRK2) is linked to various diseases, including Parkinson's disease, cancer, and leprosy. Data from LRRK2 knockout mice has highlighted a possible role for LRRK2 in regulating signaling pathways that are linked to the pathogenesis of Crohn's disease. Here, we...
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Published in | Science signaling Vol. 5; no. 207; p. pe2 |
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Main Authors | , |
Format | Journal Article |
Language | English |
Published |
United States
17.01.2012
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Subjects | |
Online Access | Get more information |
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Summary: | Leucine-rich repeat kinase 2 (LRRK2) is linked to various diseases, including Parkinson's disease, cancer, and leprosy. Data from LRRK2 knockout mice has highlighted a possible role for LRRK2 in regulating signaling pathways that are linked to the pathogenesis of Crohn's disease. Here, we examine how LRRK2's role as a signaling hub in the cell could lead to diverse pathologies. |
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ISSN: | 1937-9145 |
DOI: | 10.1126/scisignal.2002680 |