LRRK2 and human disease: a complicated question or a question of complexes?

Leucine-rich repeat kinase 2 (LRRK2) is linked to various diseases, including Parkinson's disease, cancer, and leprosy. Data from LRRK2 knockout mice has highlighted a possible role for LRRK2 in regulating signaling pathways that are linked to the pathogenesis of Crohn's disease. Here, we...

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Bibliographic Details
Published inScience signaling Vol. 5; no. 207; p. pe2
Main Authors Lewis, Patrick A, Manzoni, Claudia
Format Journal Article
LanguageEnglish
Published United States 17.01.2012
Subjects
Animals
Crohn Disease - metabolism
Disease Models, Animal
Gene Expression Regulation
Humans
Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
Mice
Mice, Knockout
Models, Biological
Models, Genetic
Neurons - metabolism
Parkinson Disease - metabolism
Protein Serine-Threonine Kinases - metabolism
Protein Serine-Threonine Kinases - physiology
Protein Structure, Tertiary
Signal Transduction
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Summary:Leucine-rich repeat kinase 2 (LRRK2) is linked to various diseases, including Parkinson's disease, cancer, and leprosy. Data from LRRK2 knockout mice has highlighted a possible role for LRRK2 in regulating signaling pathways that are linked to the pathogenesis of Crohn's disease. Here, we examine how LRRK2's role as a signaling hub in the cell could lead to diverse pathologies.
ISSN:1937-9145
DOI:10.1126/scisignal.2002680