Chagas disease immunogenetics: elusive markers of disease progression

• Published in: Expert review of cardiovascular therapy Vol. 15; no. 5; p. 367
• Main Authors: Ortega Zamora, Yelenca, Escamilla Rojas, Leidy Johana, Villa Sandoval, Elvis Mayron, Vela Porras, Joan Steven, Cossio Contrera, Edgar Yarleison, Cubides Romero, Sergio Sebastian, Carreño Ramirez, Pedro David, Urriago Losada, Hermes, De Los Rios, Carolina, Gomez Mahecha, Daniela Alejandra, Lovera Serrano, Karen Daniela, Barreto Montaña, Juan Carlos, Narvaez Caicedo, Viviana Lorena, Gutierrez, Fredy R S
• Format: Journal Article
• Language: English
• Published: England 04.05.2017
• Subjects: immunogenetics; cardiomyopathy; parasitic; Chagas; biomarkers
• ISSN: 1744-8344
• DOI: 10.1080/14779072.2017.1317591

: Chagas disease (CD) is caused by a parasitic infection. The disease usually occurs after decades of the primary infection and can involve the myocardium or the digestive system. Of note, around 30% of . infected patients develop CD while the other 70% may remain asymptomatic for their entire life. CD is usually observed as familial clustered phenomena. Moreover, individuals with chronic Chagas heart disease (CCHD) usually present a strong, deregulated immune response, which strongly suggests an immunogenetic effect. : In this article we review and discuss the information currently available from the published scientific literature regarding the genetic variants of molecules of the immune system that contribute to the clinical presentation of the disease. : Of note, the most promissory results are found on the polymorphisms of chemokine receptors, particularly CCR5 and CCR2. Additional investigations are required, particularly with a focus on the genes that regulate the immune system.