Leptin's Immune Action: A Review Beyond Satiety

The adipose tissue is an endocrine organ that secretes adipokines such as leptin, which is one of the most important hormones for controlling satiety, metabolism, and energy homeostasis. This hormone acts in the regulation of innate and adaptive immune responses since immune cells have leptin recept...

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Published inImmunological investigations Vol. 52; no. 1; pp. 117 - 133
Main Authors Abend Bardagi, Alice, dos Santos Paschoal, Clarissa, Favero, Giovanna Ganem, Riccetto, Luisa, Alexandrino Dias, Maria Luisa, Guerra Junior, Gil, Degasperi, Giovanna
Format Journal Article
LanguageEnglish
Published England Taylor & Francis 02.01.2023
Subjects
Adipocytes
Adipocytes - metabolism
Adipokines - metabolism
Adipose Tissue - metabolism
Bone Marrow
Humans
immune response
Leptin
Adipocytes
immune response
leptin
bone marrow
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Summary:The adipose tissue is an endocrine organ that secretes adipokines such as leptin, which is one of the most important hormones for controlling satiety, metabolism, and energy homeostasis. This hormone acts in the regulation of innate and adaptive immune responses since immune cells have leptin receptors from which this hormone initiates its biological action. These receptors have been identified in hematopoietic stem cells in the bone marrow and mature immune cells, inducing signaling pathways mediated by JAK/STAT, PI3K, and ERK 1/2. It is known that the bone marrow also contains leptin-producing adipocytes, which are crucial for regulating hematopoiesis through largely unknown mechanisms. Therefore, we have reviewed the roles of leptin inside and outside the bone marrow, going beyond its action in the control of satiety.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ObjectType-Review-1
ISSN:0882-0139
1532-4311
DOI:10.1080/08820139.2022.2129381