Synthesis of Alkyl Methylphosphonic Acid Esters

A synthesis and isolation scheme is described for producing mono alkyl esters of methylphosphonic acid based upon stoichiometric addition of alcohol to methylphosphonic dichloride. Solvent extraction is applied to the reaction mixture to separate the monoalkyl esters in reasonable yield from dialkyl...

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Bibliographic Details
Published inPhosphorus, sulfur, and silicon and the related elements Vol. 180; no. 8; pp. 1885 - 1891
Main Authors Mong, G. M., Harvey, S. D., Campbell, J. A.
Format Journal Article
LanguageEnglish
Published ABINGDON Taylor & Francis Group 01.08.2005
Taylor & Francis
Subjects
Chemistry
Chemistry, Inorganic & Nuclear
Chemistry, Organic
Cyclohexyl methylphosphonic acid
isopropyl methyphosphonic acid
methylphosphonic dichloride
Physical Sciences
Science & Technology
methylphosphonic dichloride
cyclohexyl methylphosphonic acid
isopropyl methyphosphonic acid
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Summary:A synthesis and isolation scheme is described for producing mono alkyl esters of methylphosphonic acid based upon stoichiometric addition of alcohol to methylphosphonic dichloride. Solvent extraction is applied to the reaction mixture to separate the monoalkyl esters in reasonable yield from dialkyl methylphosphonate and unsubstituted methylphosphonic acid. The single-alkylated materials are important hydrolysis products of the G-series nerve agents, and are not generally available from chemical suppliers.
ISSN:1042-6507
1563-5325
DOI:10.1080/104265090889602