CSF analysis for protein biomarker identification in patients with leptomeningeal metastases from CNS lymphoma

Leptomeningeal metastases (LM) from lymphoma remain a difficult complication for oncologist due to the high incidence in morbidity and mortality. Early diagnostic and initiation of treatment are essential to prevent neurological deterioration. Areas covered: In this review, several proteomic approac...

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Published inExpert review of proteomics Vol. 14; no. 4; p. 363
Main Authors Galicia, N, Dégano, R, Díez, P, González-González, M, Góngora, R, Ibarrola, N, Fuentes, M
Format Journal Article
LanguageEnglish
Published England 03.04.2017
Subjects
Biomarkers, Tumor - cerebrospinal fluid
Central Nervous System Neoplasms - cerebrospinal fluid
Central Nervous System Neoplasms - genetics
Central Nervous System Neoplasms - pathology
Humans
Lymphoma - cerebrospinal fluid
Lymphoma - genetics
Lymphoma - pathology
Proteomics
Leptomeningeal Lymphoma
proteomics
biomarkers
proteins
cerebrospinal fluid
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Summary:Leptomeningeal metastases (LM) from lymphoma remain a difficult complication for oncologist due to the high incidence in morbidity and mortality. Early diagnostic and initiation of treatment are essential to prevent neurological deterioration. Areas covered: In this review, several proteomic approaches are described in order to help and provide the basis for the identification of biomarkers useful in early diagnosis, also in discovery novel targets for therapeutic agents. In fact, the identification of biomarkers will have a high potential to detect leptomeningeal lymphoma, as well as to predict its progression and treatment response. Expert commentary: In the case of LM by Central nervous system (CNS) lymphoma, these studies generated the first insights into the utility of proteomic analysis for biomarker identification and will be demonstrated that identifying specific proteins in cerebrospinal fluid (CSF) had much greater sensitivity for detecting LM in comparison to standard cytological protocols.
ISSN:1744-8387
DOI:10.1080/14789450.2017.1307106