Antioxidant activity of anacardic acids
Anacardic acids, 6-pentadec(en)ylsalicylic acids isolated from the cashew Anacardium occidentale L. (Anacardiaceae) nut and apple, were found to possess preventive antioxidant activity while salicylic acid did not show this activity. These anacardic acids prevent generation of superoxide radicals by...
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Published in | Food chemistry Vol. 99; no. 3; pp. 555 - 562 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
Oxford
Elsevier Ltd
2006
Elsevier |
Subjects | |
Online Access | Get full text |
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Summary: | Anacardic acids, 6-pentadec(en)ylsalicylic acids isolated from the cashew
Anacardium occidentale L. (Anacardiaceae) nut and apple, were found to possess preventive antioxidant activity while salicylic acid did not show this activity. These anacardic acids prevent generation of superoxide radicals by inhibiting xanthine oxidase (EC 1.1.3.22, Grade IV) without radical-scavenging activity. Notably, the inhibition kinetics of anacardic acids do not follow hyperbolic dependence of enzyme inhibition on inhibitor contents (Michaelis–Menten equation) but follow the Hill equation instead. Anacardic acid (C
15:1) inhibited the soybean lipoxygenase-1 (EC 1.13.11.12, Type 1) catalyzed oxidation of linoleic acid with an IC
50 of 6.8
μM. The inhibition is a slow and reversible reaction without residual enzyme activity. The inhibition kinetics indicate that anacardic acid (C
15:1) is a competitive inhibitor and the inhibition constant,
K
I, was 2.8
μM. Anacardic acids act as antioxidants in a variety ways, including inhibition of various prooxidant enzymes involved in the production of the reactive oxygen species and chelate divalent metal ions such as Fe
2+ or Cu
2+, but do not quench reactive oxygen species. The C
15-alkenyl side chain is largely associated with the activity. |
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Bibliography: | http://dx.doi.org/10.1016/j.foodchem.2005.08.023 |
ISSN: | 0308-8146 1873-7072 |
DOI: | 10.1016/j.foodchem.2005.08.023 |