Cortical parvalbumin neurons are responsible for homeostatic sleep rebound through CaMKII activation

• Published in: Nature communications Vol. 15; no. 1; pp. 6054 - 19
• Main Authors: Kon, Kazuhiro, Ode, Koji L., Mano, Tomoyuki, Fujishima, Hiroshi, Takahashi, Riina R., Tone, Daisuke, Shimizu, Chika, Shiono, Shinnosuke, Yada, Saori, Matsuzawa, Kyoko, Yoshida, Shota Y., Yoshida Garçon, Junko, Kaneko, Mari, Shinohara, Yuta, Yamada, Rikuhiro G., Shi, Shoi, Miyamichi, Kazunari, Sumiyama, Kenta, Kiyonari, Hiroshi, Susaki, Etsuo A., Ueda, Hiroki R.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 18.07.2024; Nature Publishing Group; Nature Portfolio
• Subjects: 14/1; 14/63; 38/44; 38/91; 631/337/458/1733; 631/378/1385/1815; 631/378/1385/519; 631/378/2571; 64/110; 64/60; 82/51; 82/58; 82/80; 9/26; Animals; Ca2+/calmodulin-dependent protein kinase II; Calcium ions; Calcium-Calmodulin-Dependent Protein Kinase Type 2 - genetics; Calcium-Calmodulin-Dependent Protein Kinase Type 2 - metabolism; Calmodulin; Cerebral Cortex - metabolism; Excitability; Feedback inhibition; Hibernation; Homeostasis; Humanities and Social Sciences; Kinases; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; multidisciplinary; Negative feedback; Neurons; Neurons - metabolism; Neurons - physiology; Parvalbumin; Parvalbumins - metabolism; Science; Science (multidisciplinary); Sleep; Sleep - physiology; Sleep and wakefulness; Wakefulness; Wakefulness - physiology

The homeostatic regulation of sleep is characterized by rebound sleep after prolonged wakefulness, but the molecular and cellular mechanisms underlying this regulation are still unknown. In this study, we show that Ca 2+ /calmodulin-dependent protein kinase II (CaMKII)-dependent activity control of...