The beneficial effects of antioxidants combination on cardiac injury induced by tetrachloromethane

• Published in: Drug and chemical toxicology (New York, N.Y. 1978) Vol. 45; no. 3; pp. 1364 - 1372
• Main Authors: Alshanwani, Aliah R., Faddah, Laila M., Hagar, Hanan, Alhusaini, Ahlam M., Shaheen, Sameerah, Mohammad, Raeesa A., Alharbi, Fatima M. B., AlHarthii, Alaa, Badr, Amira M.
• Format: Journal Article
• Language: English
• Published: United States Taylor & Francis 04.05.2022
• Subjects: Animals; antioxidants; Antioxidants - pharmacology; Carbon Tetrachloride; cardiomyopathy; Carsil; Heart; Rats; tetrachloromethane; Tumor Necrosis Factor-alpha; vascular endothelial growth factor; Vascular Endothelial Growth Factor A - pharmacology; Carsil; cardiomyopathy; antioxidants; tetrachloromethane; vascular endothelial growth factor
• ISSN: 0148-0545; 1525-6014
• DOI: 10.1080/01480545.2020.1831012

The purpose of this research was to evaluate the efficacy of carsil (CAR) either alone or in combination with α-tocopherol (α-TOCO) and/or turmeric (TUMR) against tetrachloromethane (TCM)-induced cardiomyocyte injury in rats. Administration of CAR either alone or in combination with α-TOCO and/or TUMR post-TCM injection, significantly mitigated the increases in serum troponin T, creatine kinase-MB (CK-MB) as well as interleukin-6 (IL-6), interferon γ (IFN-γ), tumor necrosis factor-α (TNF-α), C-reactive protein (CRP). They also decline the elevation of caspase-3, vascular endothelial growth factor (VEGF) protein expression as well as DNA damage in cardiac tissues induced by TCM. The biochemical results were confirmed by histopathological investigation. Conclusion: The combination of the three antioxidants showed greater cardioprotective potential, compared to individual drugs. Therefore, this combination may be recommended as a complementary therapy to antagonize cardiac injury induced by different insults.