Regional Dynamics of the Resting Brain in Amyotrophic Lateral Sclerosis Using Fractional Amplitude of Low-Frequency Fluctuations and Regional Homogeneity Analyses

Resting-state functional magnetic resonance imaging has been playing an important role in the study of amyotrophic lateral sclerosis (ALS). Although functional connectivity is widely studied, the patterns of spontaneous neural activity of the resting brain are important mechanisms that have been use...

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Published inBrain connectivity Vol. 9; no. 4; pp. 356 - 364
Main Authors Bueno, Ana Paula Arantes, Pinaya, Walter Hugo Lopez, Rebello, Keila, de Souza, Leonardo Cruz, Hornberger, Michael, Sato, João Ricardo
Format Journal Article
LanguageEnglish
Published United States Mary Ann Liebert, Inc 01.05.2019
Subjects
Amyotrophic lateral sclerosis
Brain mapping
Cerebellum
Cognition
Cognition & reasoning
Ethics
Functional magnetic resonance imaging
Neural networks
Neuroimaging
NMR
Nuclear magnetic resonance
Oscillations
Sensorimotor system
United Kingdom > UK
Brazil
resting state
fractional amplitude of low-frequency fluctuations
regional homogeneity
spontaneous low-frequency oscillations
amyotrophic lateral sclerosis
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Summary:Resting-state functional magnetic resonance imaging has been playing an important role in the study of amyotrophic lateral sclerosis (ALS). Although functional connectivity is widely studied, the patterns of spontaneous neural activity of the resting brain are important mechanisms that have been used recently to study a variety of conditions but remain less explored in ALS. Here we have used fractional amplitude of low-frequency fluctuation (fALFF) and regional homogeneity (ReHo) to study the regional dynamics of the resting brain of nondemented ALS patients compared with healthy controls. As expected, we found the sensorimotor network with changes in fALFF and ReHo, and also found the default mode network (DMN), frontoparietal network (FPN), and salience network (SN) altered and the cerebellum, although no structural changes between ALS patients and controls were reported in the regions with fALFF and ReHo changes. We show an altered pattern in the spontaneous low-frequency oscillations that is not confined to the motor areas and reveal a more widespread involvement of nonmotor regions, including those responsible for cognition.
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ISSN:2158-0014
2158-0022
DOI:10.1089/brain.2019.0663