Serum exosomal long noncoding RNA nuclear-enriched abundant transcript 1 predicts 90-day mortality in acute-on-chronic hepatitis B liver failure

: Acute-on-chronic hepatitis B liver failure (ACHBLF) is characterized by high short-term mortality, calling for accurate prognostic biomarkers. This study aims to evaluate the predictive value of serum exosomal long noncoding RNA nuclear-enriched abundant transcript 1 (lncRNA NEAT1) for 90-day mort...

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Published inExpert review of clinical immunology Vol. 17; no. 7; p. 789
Main Authors Gao, Shuai, Fan, Yu-Chen, Han, Li-Yan, Wang, Kai
Format Journal Article
LanguageEnglish
Published England 03.07.2021
Subjects
Acute-On-Chronic Liver Failure - genetics
Acute-On-Chronic Liver Failure - mortality
Hepatitis B, Chronic - genetics
Hepatitis B, Chronic - mortality
Humans
Prognosis
Prospective Studies
RNA, Long Noncoding - genetics
LncRNA
Biomarker
NEAT1
exosome
prognosis
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Summary:: Acute-on-chronic hepatitis B liver failure (ACHBLF) is characterized by high short-term mortality, calling for accurate prognostic biomarkers. This study aims to evaluate the predictive value of serum exosomal long noncoding RNA nuclear-enriched abundant transcript 1 (lncRNA NEAT1) for 90-day mortality of ACHBLF. : This prospective study consisted of 113 ACHBLF patients from June 2013 to June 2017 as a training cohort and 72 ACHBLF patients from July 2017 to June 2020 as a validating cohort. LncRNA NEAT1 was detected using quantitative real-time polymerase chain reaction from serum exosomes. : LncRNA NEAT1 levels were higher in non-survivors than survivors ( < 0.01). In the training cohort, lncRNA NEAT1 (HR 1.049, 95%CI 1.023-1.075, < 0.001) was an independent predictor for 90-day mortality of ACHBLF. Meanwhile, lncRNA NEAT1 showed significantly higher area under the curve of receiver operating characteristic (AUC) than MELD score in the training and validation cohort ( < 0.05, respectively). However, no significant difference was found in AUC between lncRNA NEAT1 and NEAT1 plus MELD score ( > 0.05). ACHBLF patients with lncRNA NEAT1 levels above 1.92 showed poorer survival condition than those below ( < 0.01). : The serum exosomal lncRNA NEAT1 might be a better prognostic biomarker than MELD score for 90-day mortality of ACHBLF.
ISSN:1744-8409
DOI:10.1080/1744666X.2021.1933442