In Vivo Confocal Microscopic Evaluation of the Limbus and Cornea in Vogt Koyanagi Haradas Syndrome

To elucidate the microarchitecture of limbus and cornea in subjects with Vogt Koyanagi Haradas syndrome (VKH) From January 2019 to December 2019 a total of 17 VKH subjects, 5 acute and 12 chronic, 18 non VKH uveitis controls, and 6 healthy controls were recruited for this study . In vivo confocal mi...

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Published inOcular immunology and inflammation Vol. 30; no. 6; pp. 1361 - 1368
Main Authors Thundikandy, Radhika, Priya Chidambaranathan, Gowri, Radhakrishnan, Naveen, S. R, Rathinam
Format Journal Article
LanguageEnglish
Published England Taylor & Francis 18.08.2022
Subjects
corneal nerves
inflammatory cells
IVCM
keratocytes
VKH
VKH
corneal nerves
keratocytes
IVCM
inflammatory cells
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Summary:To elucidate the microarchitecture of limbus and cornea in subjects with Vogt Koyanagi Haradas syndrome (VKH) From January 2019 to December 2019 a total of 17 VKH subjects, 5 acute and 12 chronic, 18 non VKH uveitis controls, and 6 healthy controls were recruited for this study . In vivo confocal microscopic (IVCM) analysis of the limbal basal epithelium, scleral side of the limbus, limbal niche, corneal keratocytes, and corneal nerves was carried out . Absence of pigmented cells in the limbal basal epithelium, presence of inflammatory cells on the scleral side of the limbus, fibrotic niche, degenerated keratocytes, thinning, and beading of corneal nerves were noted in VKH eyes as compared to controls. Presence of inflammatory cells and depigmentation of limbus in chronic VHK points to disease progression.Keratocyte and corneal nerve changes in Vogt Koyanagi Haradas syndrom are novel findings.
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ISSN:0927-3948
1744-5078
DOI:10.1080/09273948.2021.1873395