One-pot preparation of nano-scaled magnetic-pectin particles (Fe3O4@pectin NPs): cytotoxicity, antioxidant, and anti-liver cancer properties
This work described the one-pot synthesis of orange pectin encapsulated Fe3O4 nanoparticles (Fe 3 O 4 @Pectin NPs) which is prepared by co-precipitation of Fe(II/(III) ions in alkaline solution mediated by pectin. This process led to formation of magnetic nanoparticles within the network of pectin....
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Published in | Journal of experimental nanoscience Vol. 17; no. 1; pp. 326 - 338 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
Abingdon
Taylor & Francis
31.12.2022
Taylor & Francis Ltd Taylor & Francis Group |
Subjects | |
Online Access | Get full text |
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Summary: | This work described the one-pot synthesis of orange pectin encapsulated Fe3O4 nanoparticles (Fe
3
O
4
@Pectin NPs) which is prepared by co-precipitation of Fe(II/(III) ions in alkaline solution mediated by pectin. This process led to formation of magnetic nanoparticles within the network of pectin. Physicochemical characterization of the as-synthesized Fe
3
O
4
@Pectin NPs was carried out through Fourier transformed infrared spectroscopy (FT-IR), electron microscopy (SEM and TEM), energy dispersive X-ray spectroscopy (EDX), vibrating sample magnetometer (VSM) and X-ray diffraction (XRD). The in vitro cytotoxic and anti-liver cancer effects of biologically synthesized Fe
3
O
4
@Pectin NPs against pleomorphic hepatocellular carcinoma (SNU-387), hepatic ductal carcinoma (LMH/2A), morris hepatoma (McA-RH7777), and novikoff hepatoma (N1-S1 Fudr) cancer cell lines were assessed. The anti-liver cancer properties of the Fe
3
O
4
@Pectin NPs could significantly remove pleomorphic hepatocellular carcinoma (SNU-387), hepatic ductal carcinoma (LMH/2A), morris hepatoma (McA-RH7777), and novikoff hepatoma (N1-S1 Fudr) cancer cell lines in a time and concentration-dependent manner by MTT assay. The IC
50
of the Fe
3
O
4
@Pectin NPs were 8, 13, 10, and 7 µg/mL against pleomorphic hepatocellular carcinoma (SNU-387), hepatic ductal carcinoma (LMH/2A), morris hepatoma (McA-RH7777), and novikoff hepatoma (N1-S1 Fudr) cancer cell lines. The antioxidant activity of Fe
3
O
4
@Pectin NPs was determined by DPPH method. The Fe
3
O
4
@Pectin NPs showed the high antioxidant activity according to the IC
50
value. It seems that the anti-human liver cancer effect of recent nanoparticles is due to their antioxidant effects. |
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ISSN: | 1745-8080 1745-8099 |
DOI: | 10.1080/17458080.2022.2063279 |