Generating Vectors for the Lattice Structures of Tubular and Conical Viral Capsids
Retrovirus capsid is a fullerene-like lattice consisting of capsid protein hexamers and pentamers. Mathematical models for the lattice structure help understand the underlying biological mechanisms in the formation of viral capsids. It is known that viral capsids could be categorized into three majo...
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Published in | Computational and Mathematical Biophysics Vol. 2; no. 1; pp. 128 - 140 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
De Gruyter Open
01.01.2014
Sciendo De Gruyter |
Subjects | |
Online Access | Get full text |
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Summary: | Retrovirus capsid is a fullerene-like lattice consisting of capsid protein hexamers and pentamers.
Mathematical models for the lattice structure help understand the underlying biological mechanisms in the
formation of viral capsids. It is known that viral capsids could be categorized into three major types: icosahedron,
tube, and cone. While the model for icosahedral capsids is established and well-received, models
for tubular and conical capsids need further investigation. This paper proposes new models for the tubular
and conical capsids based on an extension of the Capser-Klug quasi-equivalence theory. In particular, two
and three generating vectors are used to characterize respectively the lattice structures of tubular and conical
capsids. Comparison with published HIV-1 data demonstrates a good agreement of our modeling results
with experimental data. |
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ISSN: | 2544-7297 2299-3266 2544-7297 |
DOI: | 10.2478/mlbmb-2014-0009 |