Dietary protein restriction benefits patients with chronic kidney disease (Review Article)

• Published in: Nephrology (Carlton, Vic.) Vol. 11; no. 1; pp. 53 - 57
• Main Authors: MANDAYAM, SREEDHAR, MITCH, WILLIAM E
• Format: Journal Article
• Language: English
• Published: Melbourne, Australia Blackwell Publishing Asia 01.02.2006
• Subjects: chronic kidney failure; Diet, Protein-Restricted; Humans; Kidney Failure, Chronic - diet therapy; low‐protein diet; progression; protein intolerance; uraemic toxins
• ISSN: 1320-5358; 1440-1797
• DOI: 10.1111/j.1440-1797.2006.00528.x

The prevalence of chronic kidney disease (CKD) is rapidly increasing so every strategy should be used to avoid the complications of CKD. Most CKD symptoms or uraemia are caused by protein intolerance; symptoms arise because the patient is unable to excrete metabolic products of dietary protein and the ions contained in protein‐rich foods. Consequently, CKD patients accumulate salt, phosphates, uric acid and many nitrogen‐containing metabolic products, and secondary problems of metabolic acidosis, bone disease and insulin resistance become prominent. These problems can be avoided with dietary planning. Protein‐restricted diets do not produce malnutrition and with these diets even patients with advanced CKD maintain body weight, serum albumin and normal electrolyte values. Non‐compliance is a problem, but this can be detected using standard techniques to provide the patient with appropriate responses. The role of dietary protein restriction in the progression of CKD has not been proven, but it can reduce albuminuria and will prevent uraemic symptoms. Until a means of preventing kidney disease or progression is found, safe methods of management such as dietary manipulation should be available for CKD patients.