Synthesis of a pentasaccharide-oligonucleotide conjugate: A novel antithrombotic agent
Derivatization of the octadecathymidylate derivative 18 (T-18 ODN) containing a free amine function with sulfo-SIAB(R) gave the corresponding iodoacetyl ODN 21. Conjugation of the latter with the thiol-containing pentasaccharide 17c gave pentasaccharide-ODN conjugate III, which exhibited anti-Xa and...
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Published in | Chemistry : a European journal Vol. 2; no. 12; pp. 1572 - 1577 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
WEINHEIM
Wiley
01.12.1996
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Subjects | |
Online Access | Get more information |
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Summary: | Derivatization of the octadecathymidylate derivative 18 (T-18 ODN) containing a free amine function with sulfo-SIAB(R) gave the corresponding iodoacetyl ODN 21. Conjugation of the latter with the thiol-containing pentasaccharide 17c gave pentasaccharide-ODN conjugate III, which exhibited anti-Xa and antithrombin activities of 173 U mg(-1) and 5 U mg(-1), respectively. |
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ISSN: | 0947-6539 |
DOI: | 10.1002/chem.19960021216 |