Immunomodulatory effects of Moringa oleifera leaves aqueous extract in sheep naturally co-infected with Fasciola gigantica and Clostridium novyi
The current study was designed to evaluate the in vivo fasciolicidal activity of Moringa ( M. ) oleifera leaf aqueous extract oral administration as well as its antibacterial activity against Clostridium ( C. ) novyi in sheep naturally co-infected with fascioliasis and C. novyi . Sheep naturally inf...
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Published in | Journal of parasitic diseases Vol. 43; no. 4; pp. 583 - 591 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
New Delhi
Springer India
01.12.2019
Springer Nature B.V |
Subjects | |
Online Access | Get full text |
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Summary: | The current study was designed to evaluate the in vivo fasciolicidal activity of
Moringa
(
M.
)
oleifera
leaf aqueous extract oral administration as well as its antibacterial activity against
Clostridium
(
C.
)
novyi in
sheep naturally co-infected with fascioliasis and
C. novyi
. Sheep naturally infected with fascioliasis were divided into 3 groups, heavily infected treated group, lightly infected treated group and mixed infection control (non-treated) group. Treatment groups were orally administered
M. oleifera
leaves aqueous extract at a dose of 150 mg/kg every 48 h for 21 days. Animal body weights, fecal egg count, serum levels of anti-
Fasciola
IgG, cytokines (IL-2, IL-17, IL-10), and bacterial count of
C. novyi
were evaluated. The results showed that treatment with
M. oleifera
improved the body weight gain and decreased fecal egg count in lightly and heavily infected groups compared to the nontreated group with 100% reduction in egg count in lightly infected sheep. Furthermore, the treatment with
M. oleifera
significantly reduced the serum levels of IgG, IL-2, and IL-17. Interestingly, elevated levels of IL-10 were recorded in both heavily and lightly infected sheep. The treatment with
Moringa
extract significantly decreased the fecal bacterial count of
C. novyi
in both heavily and lightly infected groups. In conclusion, this study highlights the potential beneficial effects of
M. oleifera
leaf against
Fasciola
(
F.
)
gigantica
and
C. novyi
. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0971-7196 0975-0703 |
DOI: | 10.1007/s12639-019-01130-6 |