Reversal of heart failure in thalassemia major by combined chelation therapy: a case report

:  In patients with thalassemia major (TM) who are non‐compliant with long‐term desferrioxamine (DFO) chelation, survival is limited mainly because of cardiac complications of transfusional hemosiderosis. Combined chelation therapy with DFO and deferiprone has maximized the efficacy of the therapy a...

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Bibliographic Details
Published inEuropean journal of haematology Vol. 74; no. 1; pp. 84 - 85
Main Authors Tsironi, M., Deftereos, S., Andriopoulos, P., Farmakis, D., Meletis, J., Aessopos, A.
Format Journal Article
LanguageEnglish
Published Oxford, UK Munksgaard International Publishers 01.01.2005
Subjects
Adult
beta-Thalassemia - complications
beta-Thalassemia - drug therapy
beta-Thalassemia - metabolism
chelation
Deferoxamine - administration & dosage
Drug Synergism
Drug Therapy, Combination
heart failure
Heart Failure - drug therapy
Heart Failure - etiology
Heart Failure - physiopathology
Humans
Iron - metabolism
Iron Chelating Agents - administration & dosage
Male
Pyridones - administration & dosage
thalassemia
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Summary::  In patients with thalassemia major (TM) who are non‐compliant with long‐term desferrioxamine (DFO) chelation, survival is limited mainly because of cardiac complications of transfusional hemosiderosis. Combined chelation therapy with DFO and deferiprone has maximized the efficacy of the therapy and reduced cardiological complications. The aim of this report is to present the results of this combination in a desperate case of heart failure.
ISSN:0902-4441
1600-0609
DOI:10.1111/j.1600-0609.2004.00335.x