Salt-induced hypertension in Dahl salt-resistant and salt-sensitive rats with NOS II inhibition

• Published in: American journal of physiology. Heart and circulatory physiology Vol. 277; no. 2; pp. H732 - H739
• Main Authors: Rudd, M. Audrey, Trolliet, Maria, Hope, Susan, Scribner, Anne Ward, Daumerie, Geraldine, Toolan, George, Cloutier, Timothy, Loscalzo, Joseph
• Format: Journal Article
• Language: English
• Published: United States 01.08.1999
• Subjects: Amidines - pharmacology; Animals; Benzylamines - pharmacology; Drug Resistance - genetics; Enzyme Inhibitors - pharmacology; Female; Hypertension - chemically induced; Male; Microscopy, Video; NG-Nitroarginine Methyl Ester - pharmacology; Nitric Oxide Synthase - antagonists & inhibitors; Nitric Oxide Synthase Type II; Rats; Rats, Inbred Dahl - genetics; Sodium Chloride; Thiazines - pharmacology; Urea - analogs & derivatives; Urea - pharmacology

Whitaker Cardiovascular Institute, Evans Department of Medicine, Boston University School of Medicine, Boston, Massachusetts 02118-2394 Although recent evidence suggests that reduced nitric oxide (NO) production may be involved in salt-induced hypertension, the specific NO synthase (NOS) responsible...