Soluble and crosslinked hydrophilic films based on compositions of poly(acrylic acid) and poly(2-hydroxyethyl vinyl ether) for controlled drug release

• Published in: Journal of applied polymer science Vol. 90; no. 1; pp. 137 - 142
• Main Authors: Nurkeeva, Z. S., Mun, G. A., Khutoryanskiy, V. V., Bitekenova, A. B., Dzhusupbekova, A. B., Park, K.
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 03.10.2003; Wiley
• Subjects: Applied sciences; Biological and medical sciences; drug delivery systems; Exact sciences and technology; General pharmacology; hydrogels; irradiation; Medical sciences; Miscellaneous; miscibility; Organic polymers; Pharmaceutical technology. Pharmaceutical industry; Pharmacology. Drug treatments; Physicochemistry of polymers; poly(vinyl ethers); Properties and characterization; drug delivery systems; Swelling; Control release polymer; Oral form; Drug carrier; hydrogels; Experimental study; Property processing relationship; Radiochemical crosslinking; Vinyl ether polymer; irradiation; Alcohol polymer; Local anesthetic; Colloidal gel; Polyelectrolyte; Radiation dose; Gamma radiation; miscibility; Linear polymer; Acrylic acid polymer; Interpolymer; Kinetics; poly(vinyl ethers); Release
• ISSN: 0021-8995; 1097-4628
• DOI: 10.1002/app.12601

Soluble and crosslinked films based on compositions of poly(acrylic acid) and poly(2‐hydroxyethyl vinyl ether) were prepared. Solubility, morphology, mechanical characteristics, and swelling properties of the films were investigated. Potential applications of the polymer complex films in controlled drug delivery were also examined. © 2003 Wiley Periodicals, Inc. J Appl Polym Sci 90: 137–142, 2003