Effects of Ganoderma lucidum and krestin on subset T-cell in spleen of gamma-irradiated mice

• Published in: The American journal of Chinese medicine (1979) Vol. 23; no. 3-4; p. 289
• Main Authors: Chen, W C, Hau, D M, Wang, C C, Lin, I H, Lee, S S
• Format: Journal Article
• Language: English
• Published: Singapore 1995
• Subjects: Animals; Basidiomycota - chemistry; Flow Cytometry; Interferon Inducers - pharmacology; Male; Mice; Mice, Inbred ICR; Phytotherapy; Proteoglycans - pharmacology; Spleen - drug effects; Spleen - radiation effects; T-Lymphocytes - drug effects; Time Factors
• ISSN: 0192-415X; 1793-6853
• DOI: 10.1142/S0192415X95000341

Effects of Ganoderma lucidum (Gl) and Krestin (PSK) extracts on spleen, thymus and splenocytes in gamma-irradiated mice were investigated in this study. ICR strain male mice were divided into five groups. Group A was the normal control. Group B, the experimental control, was treated with Gl. Group C, the radiation treatment control, was treated with whole body exposure to 4 Gy gamma-irradiation (RT). Group D was treated with RT and Gl. Group E was treated with RT and PSK. The dosage of Gl was 400 mg/day/kg body weight and PSK was 500 mg/day/kg body weight. Our results indicated that the relative thymus weight in groups D and E were higher than group C on day 28 after gamma-irradiation. Group D was the highest in all the experimental groups. CD4 and CD8 splenocytes in group D were higher than group C on days 7 and 28. Gl was better than PSK in repairing the damage of subset T-cells in the spleen of gamma-irradiated mice.