Treatment with bifonazole shampoo for seborrhea and seborrheic dermatitis : a randomized, double-blind study

• Published in: Acta dermato-venereologica Vol. 72; no. 6; pp. 454 - 455
• Main Authors: SEGAL, R, DAVID, M, INGBER, A, LURIE, R, SANDBANK, M
• Format: Journal Article
• Language: English
• Published: Uppsala Acta dermato-venereologica 01.11.1992
• Subjects: Adolescent; Adult; Aged; Antibiotics. Antiinfectious agents. Antiparasitic agents; Antifungal agents; Antifungal Agents - therapeutic use; Biological and medical sciences; Dermatitis, Seborrheic - drug therapy; Double-Blind Method; Female; Follow-Up Studies; Hair Preparations; Humans; Imidazoles - therapeutic use; Male; Medical sciences; Middle Aged; Pharmacology. Drug treatments; Remission Induction; Scalp Dermatoses - drug therapy; Human; Imidazole derivatives; Skin disease; Antifungal agent; Chemotherapy; Treatment; Scalp; Shampoo; Seborrheic dermatitis; Seborrhea; Sebaceous gland
• ISSN: 0001-5555; 1651-2057
• DOI: 10.2340/0001555572454455

Forty-four patients with seborrhea and seborrheic dermatitis of the scalp were treated with either bifonazole shampoo (22 patients) or the vehicle shampoo (22 patients) in a randomized, double-blind vehicle-controlled study. The patients were instructed to wash their scalps 3 times weekly for 6 weeks and were examined every 3 weeks. Responses were evaluated by clinicians using a clinical grading of scaling, erythema and overall improvement, and also by the patients, who assessed pruritus and overall improvement, using a scale of 0 to 3. The improvement following the bifonazole shampoo was found to be significantly greater than that achieved with the vehicle shampoo in regard to the clinical evaluation of scaling (p = 0.01) as well as patient evaluation of pruritus (p = 0.008) and overall improvement (p = 0.03). No major adverse side effects were recorded.