An integrative DNA methylation model for improved prognostication of postsurgery recurrence and therapy in prostate cancer patients
•Identified and validated a 4-gene and integrative model for BCR.•4-G model was significantly associated with late recurrence (5+ years).•4-G model prognosticated postsurgical therapy (salvage RT or hormone therapy).•The integrative model outperformed PSA and the 4-G model alone for predicting BCR.•...
Saved in:
Published in | Urologic oncology Vol. 38; no. 2; pp. 39.e1 - 39.e9 |
---|---|
Main Authors | , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
Elsevier Inc
01.02.2020
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Summary: | •Identified and validated a 4-gene and integrative model for BCR.•4-G model was significantly associated with late recurrence (5+ years).•4-G model prognosticated postsurgical therapy (salvage RT or hormone therapy).•The integrative model outperformed PSA and the 4-G model alone for predicting BCR.•Integrative model prognosticated hormone therapy 3+ years postsurgery.
Patients with clinically localized, high-risk prostate cancer are often treated with surgery, but exhibit variable prognosis requiring long-term monitoring. An ongoing challenge for such patients is developing optimal strategies and biomarkers capable of differentiating between men at risk of early recurrence (<3 years) that will benefit from adjuvant therapies and men at risk of late recurrence (>5 years) who will benefit from long-term monitoring and/or salvage therapies.
DNA methylation changes for 12 genes associated with disease progression were analyzed in 453 prostate tumors. A 4-gene prognostic model (4-G model) for biochemical recurrence (BCR) was derived utilizing LASSO from Cohort 1 (n = 254) and validated in Cohort 2 (n = 199). Subsequently, the 4-G model was evaluated for its association with salvage radiotherapy (RT) and/or hormone therapy, and the additive potential to CAPRA-S to develop an integrative gene model was assessed.
The 4-G model was significantly associated with BCR in both cohorts (chi-squared analysis P≤ 0.004) and specifically, with late recurrence at 5+ years (P < 0.001, Cohort 1; P= 0.028, Cohort 2). Multivariable Cox proportional regression analysis identified the 4-G model as significantly associated with salvage RT or hormone therapy in Cohort 1 (hazard ratio (HR) 1.64, 95% confidence interval (CI) 1.29–2.10, P< 0.001) and further validated in Cohort 2 (HR 1.63, 95% CI 1.18–2.25, P< 0.001). The integrative model outperformed prostate-specific antigen and the 4-G model alone for predicting BCR and was associated with patients who received hormone therapy 3+ years postsurgery.
We have identified and validated a novel integrative gene model as an independent prognosticator of BCR and demonstrated its association with late BCR. These patients require more long-term postsurgical monitoring and could be spared the comorbidities of adjuvant therapies. |
---|---|
Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 1078-1439 1873-2496 |
DOI: | 10.1016/j.urolonc.2019.08.017 |