Circulating soluble CD36 is associated with glucose metabolism and interleukin-6 in glucose-intolerant men

• Published in: Diabetes & vascular disease research Vol. 6; no. 1; pp. 15 - 20
• Main Authors: Handberg, Aase, Lopez-Bermejo, Abel, Bassols, Judit, Vendrell, Joan, Ricart, Wifredo, Fernandez-Real, Jose M
• Format: Journal Article
• Language: English
• Published: London, England SAGE Publications 01.01.2009
• Subjects: Adult; Aged; Blood Glucose - metabolism; Blood Pressure; Body Mass Index; CD36 Antigens - blood; Diabetes Mellitus, Type 2 - blood; Glucose Intolerance - blood; Glucose Intolerance - physiopathology; Glucose Tolerance Test; Glycated Hemoglobin A - metabolism; Humans; Insulin - pharmacology; Insulin - physiology; Interleukin-6 - blood; Male; Middle Aged; Obesity - blood; Obesity - physiopathology; Platelet Count; Triglycerides - blood; sCD36; low grade inflammation; glucose intolerance; diabetes; insulin resistance; risk marker; obesity
• ISSN: 1479-1641; 1752-8984
• DOI: 10.3132/dvdr.2009.003

Recently, soluble CD36 (sCD36) levels were reported to be elevated in type 2 diabetes, and to be tightly correlated with insulin resistance. Our aim was to obtain further insight into the relationship between insulin sensitivity, low-grade inflammation and sCD36. We studied glucose-tolerant (n=90) and glucose-intolerant (n=57) moderately obese men. Insulin sensitivity was measured by the frequent sample intravenous glucose tolerance test, and sCD36 by an in-house ELISA assay. In glucose-intolerant subjects, sCD36 was negatively associated with insulin sensitivity and positively with interleukin-6 (IL-6), fasting glucose, fasting triglycerides, fat-free mass and platelet count. On multiple linear regression analyses, insulin sensitivity contributed 22% of sCD36 variance, independent of age, body mass index (BMI) and IL-6, in glucose-intolerant subjects. The level of sCD36 in subjects with glycosylated haemoglobin (HbA1C) above the mean was higher than in those with HbA1C values below the mean. Insulin sensitivity is a predictor of sCD36 in men with impaired glucose tolerance. IL-6 is related to sCD36 but does not predict sCD36 independent of insulin sensitivity and BMI.