Pathological PrP is abundant in sympathetic and sensory ganglia of hamsters fed with scrapie

Although the ultimate target of infection is the CNS, there is evidence that the peripheral nervous system (PNS) is involved in the pathogenesis of Transmissible Spongiform Encephalopathies (TSEs). We used immunocytochemistry to identify the presence of pathological accumulations of a host protein,...

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Bibliographic Details
Published inNeuroscience letters Vol. 265; no. 2; pp. 135 - 138
Main Authors MCBRIDE, P. A, BEEKES, M
Format Journal Article
LanguageEnglish
Published Shannon Elsevier 16.04.1999
Subjects
Administration, Oral
Animals
Axons - metabolism
Biological and medical sciences
Brain - metabolism
Cricetinae
Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
Ganglia, Sensory - metabolism
Ganglia, Spinal - metabolism
Ganglia, Sympathetic - metabolism
Immunohistochemistry - methods
Medical sciences
Mesocricetus
Nerve Tissue
Neurology
Nodose Ganglion - metabolism
Prions - metabolism
Scrapie - metabolism
Spinal Cord - metabolism
Staining and Labeling
transmissible spongiform encephalopathy
Vagus Nerve - metabolism
Nervous system diseases
Scrapie
Rodentia
Routing
Sympathetic nervous system
Cerebral disorder
Feeding
Virus
Infection
Vertebrata
Mammalia
Autonomic nervous system
Central nervous system disease
Degenerative disease
Prion
Hamster
Slow virus
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Summary:Although the ultimate target of infection is the CNS, there is evidence that the peripheral nervous system (PNS) is involved in the pathogenesis of Transmissible Spongiform Encephalopathies (TSEs). We used immunocytochemistry to identify the presence of pathological accumulations of a host protein, PrP, in the CNS and PNS (sensory and autonomic ganglia) of hamsters orally infected with 263K scrapie. All hamsters showed pathological deposition of PrP in most brain areas, along the length of the spinal cord, in nodose (NG) and dorsal root (DRG) ganglia and in the coeliac mesenteric ganglion complex (CMGC). In one case, scant deposition was observed along a few axons of the vagus nerve. This finding suggests that, after oral challenge, TSE infectious agent uses neural pathways and ganglia of the peripheral nervous system to reach target sites in the CNS.
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ISSN:0304-3940
1872-7972
DOI:10.1016/S0304-3940(99)00223-2