Molecular Targets of Alcohol Action: Translational Research for Pharmacotherapy Development and Screening

• Published in: Progress in molecular biology and translational science Vol. 98; pp. 293 - 347
• Main Authors: Gorini, Giorgio, Bell, Richard L, Mayfield, R Dayne
• Format: Book Chapter Journal Article
• Language: English
• Published: United States Elsevier Science & Technology 2011
• Subjects: Alcoholism - drug therapy; Alcohols - adverse effects; Animals; Biomarkers - metabolism; Drug Evaluation, Preclinical; Health Services Research; Humans; Neurology & clinical neurophysiology; Neurosciences; Pharmacology; Translational Medical Research

Alcohol abuse and dependence are multifaceted disorders with neurobiological, psychological, and environmental components. Research on other complex neuropsychiatric diseases suggests that genetically influenced intermediate characteristics affect the risk for heavy alcohol consumption and its conse...