Molecular Targets of Alcohol Action: Translational Research for Pharmacotherapy Development and Screening
Alcohol abuse and dependence are multifaceted disorders with neurobiological, psychological, and environmental components. Research on other complex neuropsychiatric diseases suggests that genetically influenced intermediate characteristics affect the risk for heavy alcohol consumption and its conse...
Saved in:
Published in | Progress in molecular biology and translational science Vol. 98; pp. 293 - 347 |
---|---|
Main Authors | , , |
Format | Book Chapter Journal Article |
Language | English |
Published |
United States
Elsevier Science & Technology
2011
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Summary: | Alcohol abuse and dependence are multifaceted disorders with neurobiological, psychological, and environmental components. Research on other complex neuropsychiatric diseases suggests that genetically influenced intermediate characteristics affect the risk for heavy alcohol consumption and its consequences. Diverse therapeutic interventions can be developed through identification of reliable biomarkers for this disorder and new pharmacological targets for its treatment. Advances in the fields of genomics and proteomics offer a number of possible targets for the development of new therapeutic approaches. This brain-focused review highlights studies identifying neurobiological systems associated with these targets and possible pharmacotherapies, summarizing evidence from clinically relevant animal and human studies, as well as sketching improvements and challenges facing the fields of proteomics and genomics. Concluding thoughts on using results from these profiling technologies for medication development are also presented. |
---|---|
Bibliography: | R. Dayne Mayfield, Waggoner Center for Alcohol and Addiction Research, The University of Texas at Austin, 2500 Speedway, MBB1.124, A4800, Austin, TX 78712, USA. dayne.mayfield@mail.utexas.edu, telephone: +1-512-232-7578, fax: +1-512-232-2525 Giorgio Gorini, Waggoner Center for Alcohol and Addiction Research, The University of Texas at Austin, 2500 Speedway, MBB1.124, A4800, Austin, TX 78712, USA. gorini@mail.utexas.edu, telephone: +1-512-232-2487, fax: +1-512-232-2525 Richard L. Bell, Indiana University School of Medicine, Institute of Psychiatric Research (PR415), 791 Union Dr., Indianapolis, IN 46202-4887, USA. ribell@iupui.edu, telephone: +1-317-278-4629, fax: +1-317-274-1365 |
ISBN: | 0123855063 9780123855060 |
ISSN: | 1877-1173 1878-0814 |
DOI: | 10.1016/B978-0-12-385506-0.00007-7 |