Complexes of glycated casein and carboxymethyl cellulose enhance stability and control release of anthocyanins

• Published in: Food research international Vol. 176; p. 113804
• Main Authors: Cui, Huijun, Jiang, Qiao, Gao, Ningxuan, Tian, Jinlong, Wu, Yunan, Li, Jiaxin, Yang, Shufang, Zhang, Shugang, Si, Xu, Li, Bin
• Format: Journal Article
• Language: English
• Published: Canada Elsevier Ltd 01.01.2024
• Subjects: Blueberry anthocyanins; Carboxymethyl cellulose; Controlled release; Encapsulation; Glycated casein; Stability; Glycated casein; Carboxymethyl cellulose; Encapsulation; Stability; Controlled release; Blueberry anthocyanins
• ISSN: 0963-9969; 1873-7145
• DOI: 10.1016/j.foodres.2023.113804

[Display omitted] •Binary & ternary complexes were prepared of ACNs with UGCA and CMC.•The addition of CMC increased ACNs encapsulation efficiency of ternary complexes.•Ultrasonic treatment reduced complexes’ size and improved encapsulation efficiency.•Ternary complexes performed greater on environmental stabilities of ACNs.•Ternary complexes controlled the release of ACNs during digestion. To improve the stability and sustained-release property of anthocyanins (ACNs), casein (CA) - dextran (DEX) glycated conjugates (UGCA) and carboxymethyl cellulose (CMC) were used to prepare ACNs-loaded binary and ternary complexes. The ACNs-loaded binary complexes (ACNs-UGCA) and ternary complexes (ACNs-UGCA-CMC) achieved by 8 min’ ultrasonic treatment with 40 % amplitude. The binary and ternary complexes showed spherical structure and good dispersibility, with the average size of 121.2 nm and 132.4 nm respectively. The anthocyanins encapsulation efficiency of ACNs-UGCA-CMC increased almost 20 % than ACNs-UGCA. ACNs-UGCA-CMC had better colloidal stabilities than ACNs-UGCA, such as thermal stability and dilution stability. Simultaneously, both of the binary and ternary complexes significantly prevented anthocyanins from being degraded by heat treatment, ascorbic acid, sucrose and simulated gastrointestinal environment. The protective effect of ACNs-UGCA-CMC was more significant. Furthermore, ACNs-UGCA-CMC showed slower anthocyanins release in simulated releasing environment in vitro and a long retention time in vivo. Our current study provides a potential delivery for improving the stability and controlling release of anthocyanins.