Pharmacokinetic-pharmacodynamic modeling of cyadox against Escherichia coli in swine

•Antibiotic resistant pathogens are a constant public health threat.•Growing threat of antibiotic resistance has led to the post antibiotic era.•PK-PD modeling: a newly developed method for dose optimization against pathogenic bacteria.•PK-PD modeling and dose optimization have significant effect to...

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Bibliographic Details
Published inMicrobial pathogenesis Vol. 135; p. 103650
Main Authors Huang, Lingli, Maan, Muhammad Kashif, Xu, Dongting, Bakr Shabbir, Muhammad Abu, Dai, Menghong, Yuan, Zonghui
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.10.2019
Subjects
Animals
Anti-Bacterial Agents - administration & dosage
Anti-Bacterial Agents - blood
Anti-Bacterial Agents - pharmacokinetics
Cyadox
Dose optimization
Escherichia coli
Escherichia coli - drug effects
Escherichia coli - physiology
Escherichia coli Infections - microbiology
Escherichia coli Infections - veterinary
Female
Ileum - microbiology
Male
Microbial Sensitivity Tests
Models, Biological
Pig
PK/PD
Quinoxalines - administration & dosage
Quinoxalines - blood
Quinoxalines - pharmacokinetics
Swine
Swine Diseases - drug therapy
Swine Diseases - microbiology
Dose optimization
Cyadox
PK/PD
Escherichia coli
Pig
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Summary:•Antibiotic resistant pathogens are a constant public health threat.•Growing threat of antibiotic resistance has led to the post antibiotic era.•PK-PD modeling: a newly developed method for dose optimization against pathogenic bacteria.•PK-PD modeling and dose optimization have significant effect to treat gastrointestinal infections.•Optimal dose of antibiotic based upon PK-PD modeling was used for effective treatment of gastrointestinal infections.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0882-4010
1096-1208
DOI:10.1016/j.micpath.2019.103650