Past-expiration-date liquid disinfectants to deactivate biological and chemical toxins on building material surfaces

• Published in: RSC advances Vol. 13; no. 41; pp. 2894 - 28911
• Main Authors: Wang, Je-Chuang, Huang, Wen-Chien, Cheng, Ken-Fa, Liu, Nien-Tung, Wu, Kuo-Hui
• Format: Journal Article
• Language: English
• Published: Cambridge Royal Society of Chemistry 03.10.2023; The Royal Society of Chemistry
• Subjects: Antiseptics; Basicity; Chemistry; Deactivation; Decontamination; Disinfection & disinfectants; E coli; Effectiveness; Expiration; Hydrogen peroxide; Ozone; Tile (material); Toxins
• ISSN: 2046-2069; 2046-2069
• DOI: 10.1039/d3ra04965e

In this study, we evaluated the deactivating efficacy of strong basicity-based (T4-102) and hydrogen peroxide-based (DF-200) disinfectants that were past their expiration date when used to deactivate biological and chemical toxins on building material surfaces. The decontamination efficacies of DF-200 and T4-102 disinfectants against dimethyl methylphosphonate (DMMP) and 2-chloroethyl ethylsulfide (2-CEES) were studied using GC-MS analysis. The bactericidal efficacies of disinfectants against Gram-negative E. coli and P. aeruginosa , and Gram-positive B. subtilis and S. aureus , were assessed in terms of the zone of inhibition, minimum inhibitory concentration (MIC), and minimum bactericidal concentration (MBC). The results indicated that the deactivation efficacy varied significantly according to the disinfectant amount, contact time, and building material. Higher efficacy of up to 99100% was observed for biological toxins, despite passing their expiration dates. Approximately 7078% of deactivation efficacies were observed for disinfectants against DMMP on the tile coupon at 100 L and 24 h contact time. Moreover, the deactivation efficacy of DF-200 was better than that of T4-102. The data presented here demonstrate that the responders may use past-expiration-date disinfectants for efficacious disinfectaion in large-scale contamination incidents. In this study, we evaluated the deactivating efficacy of T4-102 and DF-200 disinfectants that were past their expiration date when used to deactivate biological and chemical toxins on building material surfaces.