Promoters of Colistin Resistance in Acinetobacter baumannii Infections
We aimed to describe the mechanisms of colistin resistance in . Twenty-nine patients diagnosed with colistin-resistant infection were included to the study. The mutations in , , , and genes, expression of , carbapenemases, and positivity were studied. Twenty-seven (93%) of the patients received IV c...
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Published in | Microbial drug resistance (Larchmont, N.Y.) Vol. 25; no. 7; p. 997 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
United States
01.09.2019
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Subjects | |
Online Access | Get more information |
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Summary: | We aimed to describe the mechanisms of colistin resistance in
.
Twenty-nine patients diagnosed with colistin-resistant
infection were included to the study. The mutations in
,
,
, and
genes, expression of
, carbapenemases, and
positivity were studied.
Twenty-seven (93%) of the patients received IV colistin therapy during their stay, and the case fatality rate was 45%. All mutations in
and
were found to be accompanied with a mutation in
. The most common mutations were I42V and L150F in
(65%), E117K in
(65%), and A138T in
(58.6%). The colistin minimum inhibitory concentrations (MICs) of the isolates having any of these four mutations were higher than the isolates with no mutations (
< 0.001). The two most common mutations in
(I42V and L150F) were found to be associated with higher expressions of
and
and higher colistin MIC values (
= 0.010 and 0.031). All isolates were
positive.
Coexistence of the
mutation along with mutations in
indicates synergistic function of these genes in development of colistin resistance in
. |
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ISSN: | 1931-8448 |
DOI: | 10.1089/mdr.2018.0396 |