Insecticide-Insensitive Acetylcholinesterase Can Enhance Esterase-Based Resistance in Myzus persicae and Myzus nicotianae

• Published in: Pesticide biochemistry and physiology Vol. 49; no. 2; pp. 114 - 120
• Main Authors: Moores, G.D., Devine, G.J., Devonshire, A.L.
• Format: Journal Article
• Language: English
• Published: San Diego, CA Elsevier Inc 01.06.1994; Elsevier
• Subjects: ACETILCOLINESTERASA; ACETYLCHOLINESTERASE; ACTIVIDAD ENZIMATICA; ACTIVITE ENZYMATIQUE; Aphididae; AZOLE; AZOLES; Biological and medical sciences; Chemical control; Control; Fundamental and applied biological sciences. Psychology; Homoptera; INHIBICION; INHIBITION; INSECTICIDAS; INSECTICIDE; Invertebrates; MYZUS; MYZUS PERSICAE; Phytopathology. Animal pests. Plant and forest protection; PIRIMICARB; PIRIMICARBE; Protozoa. Invertebrates; RESISTANCE AUX PRODUITS CHIMIQUES; RESISTENCIA QUIMICA; Insecticide; Insecta; Biochemistry; Esterases; Acetylcholinesterase; Myzus persicae; Site of action; Target; Pest; Phytophagous; Homoptera; Pest management; Enzymatic activity; Chemical control; Aphididae; Cross resistance; Pesticide resistance; Phytopharmacology; Aphidoidea; Enzyme; Pesticides; Animal origin; Fundamental mechanism; Carboxylic ester hydrolases; Amplification; Sensitivity resistance; Arthropoda; Triazole derivatives; Hydrolases; Organophosphorus compounds; Invertebrata; Carbamate
• ISSN: 0048-3575; 1095-9939
• DOI: 10.1006/pest.1994.1038

The acetylcholinesterase in some resistant strains of Myzus persicae and its extremely close relative Myzus nicotianae showed marked insensitivity to inhibition by the established carbamate pirimicarb (>100-fold) and by triazamate, a novel triazole aphicide (>10-fold), that acts on the same target. There was no insensitivity to a range of other carbamate and organophosphorus insecticides. This resistance mechanism appears to be rare at present and was only found in a heterozygous form associated with the commonly occurring elevated E4/FE4 esterases that confer broad cross-resistance to many aphicides. This insensitive target site mechanism, even when heterozygous, enhances the esterase-based resistance to pirimicarb and triazamate by 15- to 30-fold.