Evaluation of novel organosilane modifications of paper spray mass spectrometry substrates for analyzing polar compounds

Paper spray mass spectrometry (PSMS) is currently used in different analytical fields, but less effort has been made so far to use PSMS for highly polar compounds. Such analytes usually show poor performance in PSMS due to their high affinity for common paper substrates in addition to high matrix ef...

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Published inTalanta (Oxford) Vol. 204; pp. 677 - 684
Main Authors Bambauer, Thomas P., Maurer, Hans H., Weber, Armin A., Hannig, Matthias, Pütz, Norbert, Koch, Marcus, Manier, Sascha K., Schneider, Marc, Meyer, Markus R.
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 01.11.2019
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Summary:Paper spray mass spectrometry (PSMS) is currently used in different analytical fields, but less effort has been made so far to use PSMS for highly polar compounds. Such analytes usually show poor performance in PSMS due to their high affinity for common paper substrates in addition to high matrix effects. In this study, strategies for hydrophobic modifications of commercially available paper substrates using ten different organosilanes were developed. The modified substrates were generated, characterized, and applied for PSMS analysis of polar toxins. By using the modified paper, PSMS performance of some of the toxins could be considerably increased, especially for orellanine, showing a more than 80-fold signal enhancement when substrates modified with chlorotrimethylsilane were used. For other toxins like ricinine, only small beneficial effects could be shown on PSMS performance when using modified substrates. Statistical equivalence tests showed sufficient ruggedness of the developed procedures also compared to conventional substrates. Thus, further systematic development of paper substrates modified with organosilane derivatives based on the presented study for application in PSMS should be encouraged. [Display omitted] •Comprehensive study using 10 different mono-/trichlorosilanes for paper modification.•Optimization of modification methods and characterization of modified substrates.•Improvements for paper spray MS performance were achieved for many polar toxins.•Equivalence tests proved robustness of paper spray MS performance using modified substrates.
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ISSN:0039-9140
1873-3573
DOI:10.1016/j.talanta.2019.05.095